disease modeling
and drug discovery

The ISSCR improves how stem cell science is conducted and applied in drug discovery and development. By aligning academia, industry, and regulators, we support validation, benchmarking, and adoption of more predictive, human-relevant models. This work is driven largely by the Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development.

KEY AREAS

Guidelines and Benchmarking
Establishing shared standards for evaluating stem cell-based models.

Cross-Sector Collaboration
Bringing together academia, industry, and regulators to align approaches.

Translational Case Studies
Demonstrating the predictive value of advanced models in real-world contexts.

Data & Knowledge Integration
Building shared resources and tools to support adoption and decision-making.

Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development

A global organization of industry and academic scientists working with regulatory experts to establish standards, develop tools, and build the collaborative infrastructure needed to accelerate responsible integration of stem cell-derived models, alongside the complementary use of informative animal models, into the drug development pipeline. This effort aligns with recent policy and regulatory shifts toward developing new approach methodologies (NAMs) as part of an integrated evidence framework that strengthens and enhances established drug discovery and development approaches. 

This work is made possible by:

Founding Members

Core Member

Contributing Member

Xellar Biosystems

Consortium Steering Committee & Working Groups

News

Resources

Events

This work is made possible by the Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development.
Explore all of our committees, working groups, and people.